![]() Overall, on the basis of these findings S1P signaling appears to be an appealing pharmacological target for improving skeletal muscle repair. Moreover, this lipid is crucially involved in the regulation of skeletal muscle contractile properties, responsiveness to insulin, fatigue resistance and tropism. ![]() The molecular mechanism of action of S1P in skeletal muscle cell precursors is highly complex, especially because S1P axis is under the control of a number of growth factors and cytokines, canonical regulators of skeletal muscle biology. Indeed, this lipid is known to activate muscle-resident satellite cells, regulating their proliferation and differentiation, as well as mesenchymal progenitors such as mesoangioblasts that originate outside skeletal muscle, both involved in tissue repair following an injury or disease. Many experimental findings obtained in the last 20 years demonstrate that S1P and its metabolism play a multifaceted role in the regulation of skeletal muscle regeneration. S1P can act either intracellularly or extracellularly through specific ligation to its five G protein-coupled receptors (GPCR) named S1P receptors (S1PR). S1P derives from the catabolism of sphingomyelin and is produced by sphingosine phosphorylation catalyzed by sphingosine kinase (SK). Here we review the role of S1P in the biology and homeostasis of skeletal muscle. Sphingosine 1-phosphate (S1P) is a bioactive lipid involved in the regulation of biological processes such as proliferation, differentiation, motility, and survival. 2Istituto Interuniversitario di Miologia, Italy.1Dipartimento di Scienze Biomediche, Sperimentali e Cliniche, University of Florence, Florence, Italy.Box 141, Thornton, PA 19373 would be appreciated.Chiara Donati 1,2, Francesca Cencetti 1,2 and Paola Bruni 1,2 * Suite 1 #403 Jenkintown, PA 19046 or The "J" Foundation, Inc., P.O. Interment SS Peter and Paul Cemetery.Ĭontributions in her memory to the Juvenile Diabetes Research Foundation 225 City Avenue, Bala Cynwyd, PA 19004 or Final Farewell 93 Old York Rd. Relatives and friends are invited to her viewing Tuesday February 18, 2014, 6-9 PM The Donohue Funeral Home 8401 West Chester Pike Upper Darby, PA 19082, 61 and to her Funeral Mass Wednesday 11:00 AM Sacred Heart Church, Manoa and Shelbourne Rds. Addison is also survived by her many aunts, uncles, and cousins. and Christine Kane (nee Guest) loving sister of Brooke Catherine and Jeffrey Frances Kelly, Jr. and Kristen Kelly (nee Kane) beloved granddaughter of Lorraine B.Kelly (nee McDade) and the Late Joseph F. Cherished daughter of Jeffrey Francis Kelly, Sr. ![]() Addison Marie 'Addie' Kelly Addison Marie Kelly "Addie", age 3 of Havertown, passed away suddenly February 13, 2014. ![]()
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January 2023
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